In acute coronary syndrome (ACS), there is an increase in cortisol levels, as an expression of the stress response, and C-reactive protein, as an expression of the inflammatory response, which are in turn associated with changes in the components of cellular immunity, and ultimately are predictors of clinical events. The objective of this study is to demonstrate that, within the frame of reference of ACS, beyond the thrombotic phenomenon that leads to ischemia and myocardial necrosis, there is an activation of an inflammatory and stress response, evidenced by an elevation of CRP and cortisol, respectively, and sequentially modifications in the components of cellular immunity in peripheral blood that convey prognostic value during hospitalization and after discharge. A prospective, observational, analytical, unicentric study of consecutive patients with ACS, with telephone follow-up to 6 months, will be carried out. For 2 years, all eligible patients admitted with a diagnosis of ACS to the Coronary Care Unit of the Hospital de Clínicas José de San Martín in Buenos Aires will be registered consecutively.
Are over 21 years of age and admitted to the Coronary Unit of the Hospital de Clínicas with a diagnosis of Acute Coronary Syndrome (ACS).
Agree to participate in the study through informed consent.
Concomitant diagnosis of chronic neoplastic or inflammatory disease.
Diagnosis of allergic disease, parasitic disease, asthma, or hypereosinophilic syndrome.
Severe associated valvular disease.
Acute myocardial infarction (AMI) in the previous month.
All eligible patients admitted with a diagnosis of Acute Coronary Syndrome to the Coronary Unit of the Hospital de Clínicas José de San Martín in the Autonomous City of Buenos Aires.
Cohort
Prospective
Serum cortisol.
Diagnostic testSerum cortisol levels obtained on admission.
Cardiovascular Death
Death caused by heart-related conditions.
Myocardial Infarction
The occurrence of a Myocardial Infarction (4th International Definition).
Stroke
The occurrence of a cerebrovascular event such as ischemic or hemorrhagic stroke.
Revascularization Procedures
Including coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI).
Hospitalization for Unstable Angina
Admission to the hospital due to chest pain or other symptoms indicative of unstable angina.
Correlation of the leukocyte, neutrophil, lymphocyte, and eosinophil counts with maximum levels of high-sensitivity troponin.
Correlation the leukocyte, neutrophil, lymphocyte, and eosinophil counts with total serum cortisol levels
Correlation the leukocyte, neutrophil, lymphocyte, and eosinophil counts with CRP levels.
Click on the lead sponsor to view all of their trials.
Hospital de Clinicas José de San Martín
Lead sponsor
University of Buenos Aires
Collaborator
