Central micrOperimetry and Radial OCT Evaluation in Geographic Atrophy (CORE-GA): a Prospective Pilot Study
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age55+
SponsorUniversity of California, San Francisco
About this trial
This study is being conducted to assess two imaging methods-central microperimetry and radial OCT (Optical Coherence Tomography)-in patients with Geographic Atrophy (GA) or those who are at risk of developing this condition. The study team is trying to determine whether these methods can provide more accurate measurements of GA progression toward the foveal center, the central part of the retina responsible for your sharpest, most detailed vision.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Subjects must be 55+ years of age Subjects in the "Intermediate AMD Observation Arm" must have intermediate age-related macular degeneration in one eye
Disqualifiers
Subjects with central involvement of GA. Central involvement is defined as geographic atrophy involving the foveal center point.
Non-proliferative diabetic retinopathy involving 10 or more hemorrhages or microaneurysms, or active proliferative diabetic retinopathy
Branch or central retinal vein or artery occlusion
Macular hole
Trial population
Patients with age-related macular degeneration.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Optical coherence tomography
Diagnostic testHigh-resolution imaging method used to evaluate the structure of the retina
Microperimetry
Diagnostic testA functional test that maps retinal sensitivity by measuring how well you can detect lights in different areas of your vision.
Treatment groups
80 Participants
are divided into 4 treatment groupsGroup A: Non-central geographic atrophy not being treated2 interventions
Group B: Intermediate age-related macular degeneration2 interventions
Group C: Non-central geographic atrophy currently being treated2 interventions
Group D: Non-central geographic atrophy initiating treatment2 interventions
Trial outcomes
Primary outcomes
1
Geographic atrophy progression rate
Quantify the progression rate of geographic atrophy toward the foveal center over time
Time frame
1 yearSecondary outcomes
1
Longitudinal progression of macular sensitivity over time
Measure macular sensitivity over time.
Time frame
1 yearSponsors and contacts
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Source ClinicalTrials.gov