Health TrialsbyHealthPanel

Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder

ConditionOCD
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-70
SponsorCentre Hospitalier Henri Laborit

About this trial

This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)

Understand and accept the constraints of the study

Be a beneficiary or affiliated to a Health Insurance scheme

Disqualifiers

Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)

Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)

Have a serious intercurrent pathology

Being a pregnant woman

Trial population

Patients will be recruited from the Clinical Research Unit of Poitiers. All volunteer patients included in this study will be included regardless of the degree of resistance to treatment or the severity of their disease. Patients will not be hospitalized for the duration of the study unless their condition requires it. Healthy volunteers will be recruited locally by advertisement or through acquaintances, and will be matched to each patient based on age, gender, laterality, and education level. They must not have an acute pathology being treated, nor take psychotropic drugs, nor be followed in psychotherapy. In their history, we must not find hospitalization in a psychiatric environment or a psychiatric illness according to the M.I.N.I. version 5.0.0.

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • Functional MRI

    Other intervention

    Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task

Treatment groups

100 Participants
are divided into 2 treatment groups
Group A: obsessive compulsive disorder patients1 intervention
Group B: Control Patients1 intervention

Trial outcomes

Primary outcomes

1

Cerebral activity modification during N-back task

Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

Time frame
Day 1
2

Cerebral activity modification during Stroop task

Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

Time frame
Day 1
3

Cerebral activity modification during switching task (Monsell et Mizon task )

Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

Time frame
Day 1

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Centre Hospitalier Henri Laborit

Lead sponsor

Source ClinicalTrials.gov
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