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Cerebral Blood Flow in Term and Preterm Neonates Using Doppler Ultrasonography

ConditionCerebral Blood Flow
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-48
SponsorAssiut University

About this trial

This study aims to evaluate cerebral blood flow in stable term and preterm newborns using Doppler ultrasonography. By measuring and comparing PSV, EDV, RI, and PI in the main brain arteries, the study seeks to identify normal physiological differences in cerebral perfusion across different gestational ages. The main goal is to establish reference values that can guide clinical monitoring, allow early detection of blood flow problems, and improve neuroprotective care in newborns.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Term neonates ≥ 37 weeks of gestational age.

Preterm neonates < 37 weeks' gestational age.

Hemodynamically stable infants at the time of examination.

Parental/guardian informed consent obtained.

Disqualifiers

Infants aged more than 48 hours after birth.

Neonates with major congenital anomalies (cardiac, neurological, or craniofacial).

Suspected or confirmed intracranial hemorrhage or brain malformations, such as intraventricular hemorrhage, may influence RI measurements and interfere with accurate assessment of cerebral blood flow.

Neonates requiring inotropic support at the time of scan.

Trial population

Term and Preterm Neonates

Trial design

Design model

Other

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

200 Participants
are grouped into 2 trial groups
Group A: Term Neonates
Group B: Preterm Neonates

Trial outcomes

Primary outcomes

1

Resistive Index (RI)

RI = (PSV - EDV)/PSV, indicates downstream resistance and the flexibility of cerebral vessels

Time frame
Baseline
2

Pulsatility Index (PI)

quantifies the shape of the blood flow waveform, reflecting how much the flow changes throughout the cardiac cycle.

Time frame
Baseline
3

Peak Systolic Velocity (PSV)

represents blood flow during systole and reflects cardiac output

Time frame
Baseline
4

End-Diastolic Velocity (EDV)

EDV reflects diastolic flow and the resistance in the vessels

Time frame
Baseline

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: