Health TrialsbyHealthPanel

Cerebral Connectivity and Metabolic Phenotype of Gliomas: Prospective Addition of DTI and Rs-fMRI to a Preoperative FDG PET Strategy, With Neuropsychological Correlates and Post-treatment Follow-up

ConditionGlioblastoma
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentre Paul Strauss

About this trial

The aim of this study is to determine whether the diffuse cerebral metabolic disturbances observed in glioblastoma are exclusively linked to the direct and indirect effects of tumor infiltration (particularly structural disconnection), or whether they also reflect a more global alteration of neurometabolic and neurovascular coupling mechanisms.

This approach thus aims to better understand the pathophysiological basis of cognitive impairment in glioblastoma and to characterize the impact of the disease at the level of brain networks.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adult patients

Patients with glioblastoma

Preoperative metabolic evaluation of a brain-expanding lesion

Disqualifiers

Contraindications to MRI

Minor or incapacitated adult

Patient deprived of liberty

Patient under legal guardianship

Trial design

Design model

Single group

Treatments tested in this trial

  • 18F-FDG PET/MRI with additional DTI and rs-fMRI sequences

    Other intervention

    fluorodeoxyglucose (Fluor18) (18F-FDG) PET/MRI with additional DTI and rs-fMRI sequences correlation with neuropsychological tests

Treatment groups

80 Participants
are divided into 1 treatment group
Group A: Patients with glioblastoma treated in the Department of Nuclear Medicine & Molecular ImagingOther 1 intervention

Trial outcomes

Primary outcomes

1

Correlation between cortical energy activity (FDG PET), axonal morphological connectivity (DTI - MRI), synchronous neuronal activity (rs-fMRI), and preoperative neuropsychological performance before surgery

Time frame
Before surgery

Secondary outcomes

1

correlation between cortical energy activity (FDG PET), axonal morphological connectivity (DTI - MRI), synchronous neuronal activity (rs-fMRI), and preoperative neuropsychological performance after surgery

Time frame
After surgery, through the study, i.e. for a maximum of 2 years

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Centre Paul Strauss

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: