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Cerebral Large Vessel Occlusion Stroke Multiomics Biosample Cohort

ConditionsLarge Vessel OcclusionAcute Ischemic Stroke
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorFirst Affiliated Hospital of Wannan Medical College

About this trial

This multicenter, ambispective cohort study establishes a comprehensive multiomics biobank from five stroke centers, encompassing thrombi, intracranial blood, peripheral arterial/venous blood, and clinical-laboratory-imaging-follow-up data from patients with acute ischemic stroke with large vessel occlusion (AIS-LVO).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age over 18 years.

Patients with intracranial and extracranial large vessel occlusion ischemic stroke confirmed by cerebrovascular angiography.

Availability of complete clinical and follow-up information required for the study.

Availability of blood and/or thrombus biological samples.

Disqualifiers

Patients for whom biological samples cannot be obtained;

Patients or their family members who refuse to sign the informed consent form.

Trial population

We include patients with acute large vessel occlusion ischemic stroke from at least 5 stroke centers in China.

Trial design

Design model

Cohort

Time perspective

Other

Treatments tested in this trial

  • Not applicable- observational study

    Other intervention

    Intervention is not applicable

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Number of patients with futile recanalization

mRS score ≥3 at 3 months

Time frame
From enrollment to 3 month follow-up

Secondary outcomes

1

Number of patients with specific stroke etiologies

Patients will be classified as Cardioembolism or Large artery atherosclerosis as a final stroke etiology.

Time frame
Baseline
2

Number of patients with hemorrhagic transformation

HT: secondary occurrence of bleeding within an area of the brain affected by ischemic stroke (cerebral infarction). Further stratified into: 1. symptomatic intracranial hemorrhage (sICH) and asymptomatic intracranial hemorrhage (aICH) 2. different extent: HI1, HI2, PH1, PH2

Time frame
7 days within stroke onset
3

Number of patients with infarct expansion

Patients undergoing thrombectomy had their CTAVP reexamined 24 hours later. Through CTP, it was determined whether the volume of the infarcted lesion (rCBF\<30%) had expanded compared with preoperative CTP.

Time frame
Baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

First Affiliated Hospital of Wannan Medical College

Lead sponsor

Beijing Tiantan Hospital

Collaborator

The First Affiliated Hospital of Zhengzhou University

Collaborator

Baotou Central Hospital

Collaborator

Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Collaborator

Source ClinicalTrials.gov
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