Cerebral Oximetry, Pulmonary Artery Catheter Parameters and ECMO Flow in Patients Supported With Veno-arterial ECMO

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorAssiut University

About this trial

for patients connected to VA ECMO due to cardiogenic shock, monitoring:

1. Cerebral Oximetry 2. ECMO Parameters ECMO blood flow (L/min) every 12 hours. Sweep gas flow Cannulation configuration 3. Pulmonary Artery Catheter Data and hemodynamics:

Cardiac output / cardiac index, SvO₂, Central venous pressure (CVP). 4. other variables: P/F ratio, MAP, Heart rate, Arterial blood gases, hemoglobin, Lactate, Vasopressor / inotrope doses and Sedation score (RASS). 5. Echocardiography parameters: recorded every 12 hours. LV ejection fraction. LVOT VTi. LVED dimension. Aortic valve opening. 6. Follow-up data:

* ECMO duration. * Need for oxygen therapy/mechanical ventilation. * ICU survival.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 18 years

Patients supported with veno-arterial ECMO.

Presence of a pulmonary artery catheter.

Expected ECMO support ≥ 24 hours.

Disqualifiers

Pre-existing severe neurological injury (e.g. massive stroke, traumatic brain injury).

Intracranial pathology affecting NIRS reliability.

Facial or scalp conditions preventing NIRS probe placement.

ECMO duration < 48 hours.

Trial population

patient, aged more than 18 years old with cardiogenic shock unresponsive to conventional medical treatment and supported with VA ECMO.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

correlation between native cardiac output/ Extracorporeal membrane oxygenation flow ratio and regional cerebral tissue oxygen saturation

Time frame
from date of randomization until the date of ending the ECMO support (assessed up to 100 weeks)

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Cairo University/ECMO unit

Collaborator

This trial is not recruiting at the moment. You can still explore other options: