Change in MAPSE During Treatment of Sepsis

ConditionSepsis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Maryland, Baltimore

About this trial

Patients with bloodstream infections (sepsis) have been found in prior studies to have infection-related heart dysfunction, even if they did not have preexisting heart problems. Factors related to the infection may cause the heart to not pump as well as it should, causing critical illness in the form of low blood pressure (shock) and heart failure. Ultrasound is frequently used in the emergency department to evaluate why a patient might have low blood pressure. Part of that evaluation may include obtaining ultrasound images and making measurements about how well or poorly the heart is pumping. The investigators will evaluate a certain measurement that relates to cardiac function, determine how it changes in patients before and after they are treated for septic shock. This will involve placing an ultrasound probe on the patient's chest, measuring the upward and downward movement of the mitral valve, the mitral annulus systolic plane excursion (MAPSE), and comparing the measurements before and after treatment is started. The investigators are attempting to determine if this measurement improves before and after treatment.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Diagnosis of Sepsis or Septic Shock

Disqualifiers

Age equal to or less than 17

patient in the emergency department

Unable to perform POCUS exam due to medical necessity

Patients without sepsis

Trial population

adult emergency department patients who present with sepsis

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Treatment of Sepsis

    Other intervention

    Patients will have standard care of sepsis

Treatment groups

50 Participants
are divided into 1 treatment group
Group A: Patients with Sepsis1 intervention

Trial outcomes

Primary outcomes

1

Change in MAPSE measurement

Does the MAPSE change after treatment of MAPSE

Time frame
1 hour after treatment initiation

Secondary outcomes

Other outcomes

Sponsors and contacts

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