Acute ischaemic stroke (AIS) results in high rates of neurological morbidity and mortality, especially in patients with large vessel occlusion (LVO). Endovascular therapy (EVT) has been approved as the most effective treatment for patients with LVO , but about half patients undergoing EVT did not achieve good outcome. The mechanisms of poor prognosis are complex. How to accurately identify serological biomarkers related to patients' clinical prognosis is an important research topic nowadays.
Age: 18-80 years;
Patients with acute anterior circulation large vessel occlusion within 24 hours of onset who will receive endovascular treatment;
Pre-stroke mRS: 0-1;
Baseline NIHSS: ≥6;
The presence of contraindications to internal jugular vein cannulation;
Receiving intravenous thrombolysis;
Haemorrhagic stroke (cerebral haemorrhage or subarachnoid haemorrhage);
Coagulation disorders, systemic bleeding tendency, thrombocytopenia (<100×109/L);
Patients with acute anterior circulation large vessel occlusion within 24 hours of onset who will receive endovascular treatment
Cohort
Prospective
endovascular treatment
Procedure/Surgeryall patients with anterior circulation large vessel occlusion will receive endovascular treatment.
Dynamic changes in serum biomarkers after endovascular treatment
These biomarkers will be identified based on proteomic methods
favourable functional outcome, defined as modified Rankin Scale (mRS) 0-2
mRS ranges from 0-6, high score means poor outcome
excellent functional outcome, defined as modified Rankin Scale (mRS) 0-1
mRS ranges from 0-6, high score means poor outcome
distribution of modified Rankin Scale (mRS) score
mRS ranges from 0-6, high score means poor outcome
early neurological improvement, defined as 4 or more decrease in National Institute of Health stroke scale (NIHSS)
NIHSS ranges from 0-22, with high score meaning severe neurological deficit.
the association between cerebral circulation time (CCT) and clinical outcomes
CCT is defined as the time from the appearance of contrast at the siphon segment of the internal carotid to the end of the arterial phase during DSA on the anteroposterior and lateral image in anterior circulation LVO; clinical outcomes include changes in NIHSS and mRS
the association between serum biomarkers and clinical outcomes
serum biomarkers include those in different timepoints or their dynamic changes; clinical outcomes include changes in NIHSS and mRS
the association between serum biomarkers and status of vessel recanalization
serum biomarkers include those in different timepoints or their dynamic changes; the status of vessel recanalization is determined by modified thrombolysis in cerebral infarction
Click on the lead sponsor to view all of their trials.
