Changes in Attentional Control After a Focal Seizure.
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorUniversity Hospital, Lille
About this trial
Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI. However, to date, no study has assessed the changes in attentional control after a seizure. The investigators hypothesize that a localized discharge is associated with a disorganization of the networks engaged in attentional control. In this regard, the investigators propose a prospective longitudinal study assessing the changes in attentional control after a focal seizure.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age superior to 18 and under 80
Focal epilepsy with indication to pre-surgery work-up and 5 days programmed hospitalization dedicated to this work-up
Normal global cognitive performance (standard progressive Raven matrices score > 5th percentile)
Be affiliated to the social security system
Disqualifiers
Pregnancy or breastfeeding
Not able to give consent (Article 1121-8 of the CSP)
Vulnerable person
Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP)
Trial population
Administration of the subtest of divided attention of the Test of Attentional Performance (TAP), recording of the event related potentiels N200 and P300, measure of the variation of power in several frequency bands (theta, alpha and beta) and measure of the high-resolution EEG connectivity during an attentional task at several time-points : a first time during interictal period (no seizure for more than 24 hours) and 1, 3, 6 and 24 hours after a focal seizure.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
All included subjects
Other interventionAdministration of the subtest of divided attention of the Test of Attentional Performance (TAP), recording of the event related potentiels N200 and P300, measure of the variation of power in several frequency bands (theta, alpha and beta) and measure of the high-resolution EEG connectivity during an attentional task at several time-points : a first time during interictal period (no seizure for more than 24 hours) and 1, 3, 6 and 24 hours after a focal seizure.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Subtest of divided attention of the Test of Attentional Performance (TAP)
A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Time frame
24 hoursSecondary outcomes
1
N200 amplitude and latency
A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Time frame
24 hours2
Strength of EEG functionnal connectivity during an attentional task (global and regional)
A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Time frame
24 hours3
Variation of power in several frequency bands (theta, alpha and beta) during an attentional task.
A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Time frame
24 hours4
Magnetic resonance imaging functional connectivity.
Time frame
up to 5 daysSponsors and contacts
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Source ClinicalTrials.gov