About this trial
Prospective study with inclusion of bariatric surgery candidates with diagnosed Obstructive Sleep Apnea and requiring treatment with Continuous Positive Air Pressure, aiming to evaluate at 2-6-12 months after bariatric surgery whether the relationship between biometric changes (reduction in neck circumference, height, waist/hip ratio, and fat and lean mass) and the resolution of OSA is better than the relationship between these biometric changes and BMI reduction.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
eligible for bariatric surgery: with severe obesity (BMI≥35-40) or morbid obesity (BMI≥40), with co-morbidities, who have not lost enough weight with prior lifestyle adaptations (balanced diet, physical activity) AND
with diagnosed obstructive sleep apnoea (OSA) (AHI > 15/hr on polysomnography) AND
requiring treatment with Continuous Positive Air Pressure (CPAP)
Disqualifiers
Cognitive impairment - language barrier
Trial population
Eligible patients from CHU St Pierre hospital setting
Trial design
Case-only
Prospective
Treatments tested in this trial
Bariatric surgery
Procedure/SurgeryBariatric surgery includes (but is not limited to) * Gastric bypass: surgical bypass of the entire stomach, duodenum and approximately 1 m of the proximal small intestine * Sleeve: a large part of the stomach is removed laparoscopically, the open vertical edges are put back in place to leave a sleeve-like tube. Bariatric surgery is considered a treatment option * for patients with a BMI \>40 kg/m 2 , assuming the patient has previously participated successfully in a group weight management programme (weight loss \>7%) or * for patients with a BMI of 35-40 kg/m 2 when the obesity is associated with type 2 diabetes or hypertension, or OAS (with CPAP therapy) or severe musculoskeletal disease
Treatment groups
Trial outcomes
Primary outcomes
Comparison of (1) the relationship between waist circumference changes and resolution of obstructive sleep apnea and (2) the relationship between the changes in waist circumference and BMI
Comparison of (1) the correlation between waist circumference reduction and resolution of OAS (AHI\<10/hour on polysomnography) and (2) the correlation between waist circumference reduction and BMI reduction
Comparison of (1) the relationship between waist circumference changes and resolution of obstructive sleep apnea and (2) the relationship between the changes in waist circumference and BMI
Comparison of (1) the correlation between waist circumference reduction and resolution of OAS (AHI\<10/hour on polysomnography) and (2) the correlation between waist circumference reduction and BMI reduction
Comparison of (1) the relationship between waist circumference changes and resolution of obstructive sleep apnea and (2) the relationship between the changes in waist circumference and BMI
Comparison of (1) the correlation between waist circumference reduction and resolution of OAS (AHI\<10/hour on polysomnography) and (2) the correlation between waist circumference reduction and BMI reduction
Secondary outcomes
Comparison of (1) the correlation between neck circumference reduction and OAS resolution and (2) the correlation between neck circumference reduction and BMI reduction
Comparison of (1) the correlation between neck circumference reduction and OAS resolution (AHI\<10/hour on polysomnography) and (2) the correlation between neck circumference reduction and BMI reduction
Comparison of (1) the correlation between neck circumference reduction and OAS resolution and (2) the correlation between neck circumference reduction and BMI reduction
Comparison of (1) the correlation between neck circumference reduction and OAS resolution (AHI\<10/hour on polysomnography) and (2) the correlation between neck circumference reduction and BMI reduction
Comparison of (1) the correlation between neck circumference reduction and OAS resolution and (2) the correlation between neck circumference reduction and BMI reduction
Comparison of (1) the correlation between neck circumference reduction and OAS resolution (AHI\<10/hour on polysomnography) and (2) the correlation between neck circumference reduction and BMI reduction
Comparison of (1) the correlation between hip circumference reduction and OAS resolution and (2) the correlation between hip circumference reduction and BMI reduction
Comparison of (1) the correlation between hip circumference reduction and OAS resolution (AHI\<10/hour on polysomnography) and (2) the correlation between hip circumference reduction and BMI reduction
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