Changes in Neuroplasticity Following Intensive Rehabilitation of Aphasia and/or Apraxia of Speech
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorKarolinska Institutet
About this trial
The present study aims to investigate the short- and long-term effects of two weeks of intensive speech-language pathology intervention with additional physiotherapy, on aphasia and apraxia of speech (AOS) and their neural correlates in thirty persons with chronic stroke. Changes are studied following intensive treatment of aphasia and AOS with standardised speech-language testing and testing of communication and with voxel-based morphometry (VBM) analysis and resting state functional connectivity (rsFC).
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Aphasia 7 months post stroke diagnosed by SLP
Apraxia of Speech 7 months post stroke diagnosed by SLP
Disqualifiers
Dementia
Severe loss of sight
Severe loss of hearing
Metal implants (preventing fMRI)
Trial design
Design model
Single group
Treatments tested in this trial
Multimodal Intensive Rehabilitation of Aphasia and Apraxia of Speech
BehavioralIntensive Comprehensive Aphasia (ICAP) and Apraxia of Speech Program
Treatment groups
30 Participants
are divided into 1 treatment groupGroup A: Multimodal Intensive Rehabilitation of Aphasia/AOS (MIRAA)Experimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Comprehensive Aphasia Test (CAT) language battery, in pilot Swedish test A-ning.
Comprehension of spoken language: minimum score 0, maximum score 66; Comprehension of written langugage: minimum score 0, maximum score 62; Repetition: minimum score 0, maximum score 74; Naming: minimum score 0, maximum score no limit; Reading: minimum score 0, maximum score 70; Writing: minimum score 0, maximum score 76. Higher scores mean better outcome in language functions.
Time frame
Changes from baseline in language battery scores at 2 and 18 weeks.2
Rating scale for apraxia of speech (SkaFTA, Swedish version of ASRS)
Minimum score 0, maximum score 52. Lower scores mean better outcome in speech functions.
Time frame
Changes from baseline scores at 2 and 18 weeks.3
Communication Outcome After Stroke (COAST)
Minimum score 0, maximum score 100. Higher scores mean better outcome in communication.
Time frame
Changes from baseline scores at 2 and 18 weeks.4
Goal Attainment Scaling (GAS), International Classification of Functioning, Disability and Health (ICF). Aphasia adapted GAS scales for self-evaluation of communication functions, participation and activity.
Minimum score -2, maximum score +2. Higher scores mean better outcome in quality of life.
Time frame
Changes from baseline at week 18.Secondary outcomes
1
Barrow Neurological Institute Screening for Higher Cerebral Function (BNIS)
Minimum score 0, maximum score 50. Higher scores mean better outcome in cognition.
Time frame
Changes from baseline at week 22
Boston Naming Test (BNT)
Minimum score 0, maximum score 60. Higher scores mean better outcome in naming ability.
Time frame
Changes from baseline at week 2 and week 18.3
Protocol for Apraxia of Speech (TAX)
Minimum score 0, maximum score 30. Lower scores mean mean better outcome in speech functions and non verbal oral apraxia.
Time frame
Changes from baseline at week 2 and week 18.4
Comprehensive Aphasia Test (CAT), subtest cognitive screening
Minimum score 0, maximum score 38. Higher scores mean better outcome in cognitive functions.
Time frame
Changes from baseline in Comprehensive Aphasia Test cognitive screening scores at 2 and 18 weeks.Sponsors and contacts
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Karolinska Institutet
Lead sponsor
University of Malaga
Collaborator
Source ClinicalTrials.gov