Clinical assessment of bleeding and calculation of perioperative blood loss do not provide an accurate estimate of blood volume. This makes rational fluid management difficult, which is of high importance for patient-related outcomes. The availability of carbon monoxide(CO)-rebreathing allows for simple, non-invasive and precise measurement of changes in blood volume.
The purpose of the study is to investigate and describe changes in blood volume and fluid distribution perioperative in patients undergoing total hip arthroplasty. Furthermore, to investigate the association between changes in blood volume and incidence of orthostatic insufficiency.
Patients scheduled for an elective total hip arthoplasty (THA) in a standardized fast track setting.
Capable of participating in CO-rebreathing measurement
Age ≥ 18 years
Able to speak and understand Danish
Intraoperative blood loss exceeding 750 mL.
Perioperative need for a blood transfusion.
Confirmed or suspected coagulopathies.
Factors that make CO-rebreathing measurement impossible.
Patients scheduled for an elective total hip arthoplasty (THA) at Hvidovre University Hospital and undergo the proceduce under spinal anesthesia with propofol sedation.
Cohort
Prospective
Not listed
Change in total blood volume (TBV)
Measured in milliliter (mL)
Change in total blood volume (TBV)
measured in mL
Changes in total hemoglobin mass (tHgb)
Measured in gram (g)
Changes in erythrocyte volume (EBV)
Measured in mL
Changes in plasma volume (PV)
Measured in mL
Intraoperativ estimation of bleeding
Measured by weighting gauze (gram)
Intraoperative bleeding
Measured by visual estimation in surgical drains (mL)
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