Changes in Sensitivity, Taste and Smell in Stroke Patients

ConditionsDysphagia Stroke

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorUniversity of Giessen

About this trial

This study evaluates changes in swallowing using endoscopic swallowing studies and measuring of pharyngeal sensitivity, taste and smell in stroke patients. Younger (\<60 years) and older (\>60 years) volunteers will serve as control.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

informed consent

new supratentorial stroke (<72 hours old) confirmed by CT (computed tomography) or MRI (magnetic resonance imaging)

Disqualifiers

pre-existing stroke oder dysphagia

extensive white matter lesions in CT- or MRI-scan

allergies to odorous substances or flavoring

contraindications for FEES (flexible endoscopic evaluation of swallowing), CT or MRI (stroke patients only)

Trial population

Stroke patients are recruited in a university hospital's department of neurology. Volunteers \>60years are recruited in a trauma surgery ward at the same university hospital. Volunteers \<60 are recruited without specified characteristics (aside from in-/exclusion criteria).

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

FEES (flexible endoscopic evaluation of swallowing)
Diagnostic test
Endoscopical swallowing study in stroke patients only
Sensitivity threshold
Other intervention
Determining sensitivity threshold using a pudendal electrode
Taste-/smell-test
Diagnostic test
Taste-/smell-test
Neuropsychological testing
Diagnostic test
Neuropsychological testing for neglect, agnosia

Treatment groups

200 Participants

are divided into 3 treatment groups

Group A: Volunteers <60 years2 interventions

Group B: Volunteers >60 years2 interventions

Group C: Stroke patients4 interventions

Trial outcomes

Primary outcomes

Dysphagia

Changes found in endoscopic swallowing study : Presence and severity of dysphagia (measured with Rosenbek's Penetration/Aspiration-scale)

Time frame