Obesity is a chronic disease characterized phenotypically by an increase in body weight (BMI\>30 kg/m2) and by a series of associated pathologies, such as hypertension, diabetes, hepatic steatosis.
The association of these pathologies compromises the patient's survival and quality of life. The multifactorial origin of obesity makes its etiopathology difficult to manage. It is often possible to follow only one therapeutic strategy, especially after the so-called standard treatments, such as dietary intervention and physical activity, have not brought benefit to the patient. In these cases, an appropriate treatment for the patient to enjoy significant weight loss is bariatric surgery.
Bariatric surgery refers to all those interventions aimed at reducing weight in those suffering from obesity, and treating the diseases associated with it.
Among the different types of bariatric surgery, the techniques most used in common clinical practice are intragastric balloons, gastric by pass (RYGB) and sleeve gastrectomy.
The choice of the surgeon, assisted by the multidisciplinary team, is binding in the choice of the type of operation to which the patient will be subjected.
Obese patients (BMI >30kg/m2) suffering from hepato-biliary pathology diagnosed by Fibroscan
Adult patients (>18 years).
Patients who are not obese or not affected by hepato-biliary pathology
Obese patients with hepato-biliary pathology, who refer to the nutrition clinic
Case-control
Other
Nutritional Approach
Other interventionNutritional Approach
Surgery Approach
Other interventionBariatric surgery
Variation of lipidomic parameters
Variation of lipidomic parameters measured by extraction of fatty acids from red blood cells and run in gas chromatography
The effect of intervention on routine blood chemistry parameters, relating to NAFLD and fibrosis
Evaluate how bariatric surgery affects routine blood chemistry parameters. The following will be taken into consideration: Blood sugar, Glycated hemoglobin, triglycerides, total cholesterol, HDL and LDL, transaminases, γGT, creatinine, uric acid
Variation in the microRNA profile
Evaluation of microRNA profile change by real-time PCR
Click on the lead sponsor to view all of their trials.
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Lead sponsor
Notarnicola Maria
Collaborator
Cozzolongo Raffaele
Collaborator
Shahini Endrit
Collaborator
De Pergola Giovanni
Collaborator
Lippolis Giuseppe
Collaborator
