Characterisation of MNEsic Involvement in Patients With Obesity.
ConditionObesity (Disorder)
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age30-50
SponsorUniversity Hospital, Bordeaux
About this trial
The aim of the study is therefore to characterise memory impairment in a middle-aged population with obesity and to clarify the role of inflammation in obesity-related memory impairment.
The hypothesise that, as in an elderly population, neurological and memory impairment in a population of middle-aged obese individuals is heterogeneous, with varying levels of memory impairment characterised by neuropsychological test results. This heterogeneity in neuropsychological tests may be linked to markers of inflammation and brain imaging biomarkers identified previously in the litterature.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients suffering from obesity with a BMI between 30 and 45 kg/m²
Patients aged between 30 and 50 receiving educational care during the week at the CSO (Endocrinology, Diabetology and Nutrition Department) of the Bordeaux University Hospital.
Right-handed patients
Persons affiliated with or beneficiaries of a social security scheme.
Disqualifiers
Patients currently undergoing treatment with neuroleptics or who have stopped treatment within the last 3 months.
Pregnant or breastfeeding patients
Known current or past neurological disease
Proven depressive syndrome treated
Trial population
Recruitment will take place within the Specialised Obesity Centre at Bordeaux University Hospital. As part of their obesity treatment within the department, new patients first attend a consultation, after which they are usually admitted for a five-day educational programme to undergo a comprehensive initial multidisciplinary assessment (covering medical, dietary, psychological, physical activity and social aspects).
Trial design
Design model
Other
Time perspective
Prospective
Treatments tested in this trial
RMI and Questionnaires
Other interventionMagnetic resonance imaging (MRI) will collect anatomical information (3D T1 weighted images) to compute the volumes of the hypothalamus, hippocampus and the other brain parcels. Executive functions using the CANTAB tests and validated questionnaires will be performed.
Treatment groups
150 Participants
are divided into 1 treatment groupGroup A: Magnetic Resonance Imaging, CANTAB questionnaires1 intervention
Trial outcomes
Primary outcomes
1
Memory function characteristic
The main objective is to characterise memory function in a population of middle-aged individuals suffering from obesity using the CANTAB Paired Associates Learning (PAL) test.
Time frame
37 months after inclusion dayLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: