The distribution of demographic, clinical, radiological, pathological and molecular characteristics of lung cancer at the time of diagnosis, as well as preferential association between elements of those domains, have not been specifically studied in Italy. The aim of the present project is to assess, in a systematic fashion, the demographic, clinical, radiological, pathological and molecular characteristics of advanced lung cancer at the time of diagnosis in a large Italian cohort of consecutive patients referred to two tertiary referral centers.
Age >18 years
Suspicion of lung cancer based on imaging (CT and/or PET/CT)
Indication to a biopsy for diagnosis, staging and/or molecular profiling
Inability or unwillingness to provide a written informed consent
ECOG performance status (>3) which makes a tissue diagnosis unfeasible
ASA 4 status
TNM Stage I-III
Consecutive, treatment-naïve, patients with clinical and radiological suspicion of advanced lung cancer referred for the initial diagnosis/staging/molecular profiling.
Cohort
Prospective
Advanced lung cancer patients' group
Other interventionEvaluation of the demographic, clinical, histological and molecular characteristics of advanced lung cancer at the time of Diagnosis
Distribution of histologic subtypes
The investigators will assess the prevalence of histologic subtypes in patients with advanced lung cancer
Distribution of histologic subtypes according to clinical and radiological characteristics
The investigators will assess the prevalence of different histologic subtypes according to clinical and imaging characteristics
Molecular profiling
Prevalence of individual molecular markers in patients with advanced non-squamous non-small cell lung cancer histology
Time to diagnosis
Time lag between onset of symptoms (if any) and invasive testing
Click on the lead sponsor to view all of their trials.
