Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study

ConditionHypophosphatasia

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorUniversity of Bonn

About this trial

Non-interventional, prospective, multi-center investigation with exploratory data analysis to assess the proportion of patients with hypophosphatasia presenting at departments of rheumatology and to establish an algorithm to HPP diagnosis

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Written informed consent

Age > 18 years

Clinical suspicion of hypophosphatasia

Evidence of an abnormal ALP (ALP below LLN) within the clinical routine screening

Disqualifiers

Failure to meet the inclusion criteria listed above

Trial population

Any adult patient presenting at the participating study site's rheumatology department with musculoskeletal complaints within the timeframe of the study conduct.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Second alkaline phosphatase measurement
Diagnostic test
(1-4 weeks after the 1st measurement)

Treatment groups

720 Participants

are divided into 2 treatment groups

Group A: Persistant hypophosphatasemia1 intervention

Group B: Transient hypophosphatasemia (Control group without hypophosphatasia)1 intervention

Trial outcomes

Primary outcomes

Prevalence of hypophosphatasia in adult patients in rheumatology

The primary aim of this prospective observational study is to determine the prevalence of hypophosphatasia in adult patients presenting with musculoskeletal symptoms in rheumatology.

Time frame

36 months

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Bonn

Lead sponsor

Source ClinicalTrials.gov

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