The present study is therefore aimed at investigating the prevalence of hepatic alterations (laboratory and imaging) in adult patients with TS and generating hypothesissto the possible etiopathogenetic factors most involved, as well as evaluating the correlation between biochemical and structural abnormalities.
Thus, the study could provide relevant etiopathogenetic and prognostic results on the development of hepatopathy in TS patients.
Diagnosis of Turner syndrome made by karyotype analysis on peripheral blood.
Age 18 years or older
Written informed consent obtained
TS patients on therapy with drugs responsible for significant liver enzyme alterations (liver function alteration, LFA).
The study population will be enrolled from the cohort of adult TS patients under longitudinal monitoring at the U.O.C. of Endocrinology and Diabetes Prevention and Care IRCCS Policlinico S. Orsola.
Cohort
Retrospective
Not listed
Factors associated with hepatopathy
Hepatopathy, defined as the presence of at least one of the following conditions: * AST ≥ 35 UI/L * ALT ≥ 35 UI/L * GGT ≥ 38 UI/L * ALP ≥ 116 UI/L * Presence of hepatic steatosis
Comparison of liver morpho-functional parameters with results obtained by fibroscan.
Liver stiffness measurement (kPa)
Comparison of liver morpho-functional parameters with results obtained by fibroscan.
Spleen stiffnes measurement (kPa)
Click on the lead sponsor to view all of their trials.
