The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is:
Is the JAK1/2 pathway overactivated in periodontitis compared to health?
Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.
Adults
Sistemically healthy
Active Maliganancy
History of radiation to the head-neck region
Chemotherapy or radiation within the last 5 years
History of hepatitis B/C or HIV infection
Adults from the northern area of Santiago, Chile
Case-control
Cross-sectional
Not listed
JAK1/2 pathway activation in gingival tissues
The activation of the JAK1/2 pathway will be evaluated by the phophorilation of JAK1/2 in the gingival tissues determined by western blot. Patients will be categorizied as 0, 1, 2. 0 = no phosphorilation 1. = mild phosphorilation 2. = intense phosphorilation
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