This is a prospective observational study to be conducted in intensive care units of Global South countries. Patients on mechanical ventilation for more than 12 hours who have initiated the weaning process and for whom the attending team plans extubation within the next 6 hours will be included. Data will be collected for each patient during the first 7 days after extubation, with follow-up until hospital discharge or death. We plan to conduct the study in intensive care units from Global South countries (low- and middle-income countries predominantly located in the Southern Hemisphere, though some in the Northern Hemisphere are also considered).
Age > 18 years.
Receiving care at an intensive care unit.
Endotracheal intubation.
Mechanical ventilation for 12 hours or more.
Patients with prior extubation failure.
Patients with prior spontaneous breathing trial failure.
Patients unable to obey commands.
Neuromuscular disease or cervical spinal cord injury.
Patients receiving mechanical ventilation for more than 12 hours who are planning to undergo the first separation attempt from the invasive mechanical ventilation (as defined in the WIND Classification) in the next 6 hours or that has undergone a separation attempt less than 2 hours ago will be included.
Cohort
Prospective
Not listed
Extubation failure within 7 days.
Defined as reintubation or death within 7 days after extubation.
Extubation within 28 days.
Defined as extubation within 28 days after first separation attempt.
Intensive care unit length of stay.
Defined as the number of days from the time of first separation attempt until discharge from the intensive care unit.
Hospital length of stay.
Defined as the number of days from the time of first separation attempt until discharge from the hospital.
Reintubation or death within 28 days.
Defined as composite criterion of reintubation or death within 28 days after first separation attempt.
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