The study investigates how external, physiological, and behavioral factors influence the measurement of regional tissue oxygenation using two-dimensional near-infrared spectroscopy (NIRS) imaging in healthy volunteers. It aims to improve the standardization and reliability of this non-invasive method for assessing microvascular perfusion and tissue oxygenation.
The study also examines the effects of temporary vascular occlusion, ambient temperature, physical activity, caffeine consumption, and nicotine consumption on NIRS-based tissue oxygenation measurements. The findings are intended to establish a standardized measurement protocol for future clinical research and the assessment of microvascular perfusion in critically ill patients.
Healthy volunteers aged 20-40 years
Written informed consent
Ability to understand and comply with the study procedures
Age below 20 years or above 40 years
Cardiovascular disease or other relevant medical conditions
current medication, where relevant to the study procedures
contraindication to or inability to undergo the planned examinations
healthy volunteers
Cohort
Prospective
Not listed
microvascular tissue oxygenation
StO₂, expressed as a percentage
Retinal funduscopy parameters
measured by NIRS
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