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Child-Parent Familial Hypercholesterolemia Screening

ConditionFamilial Hypercholesterolemia
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-3
SponsorChildren's Hospital of Fudan University

About this trial

Child-parent screening for familial hypercholesterolemia has been proposed to identify children and their parent who are carrier of mutations and with high risk for inherited premature coronary artery disease. The investigators assessed the efficacy and feasibility of such screening in primary care practice.

key scientific questions:

1. The 95th and 99th percentile of finger blood TC in children of 2 years old. 2. Mutations that contribute to high TC status ( serum TC \>99th percentiles) compared with international FH48 panel for FH genetic screening.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Receive routine child care

aged 1 - 3 years old ( date of investigate minus date of birth)

Disqualifiers

It is up to the researcher to decide whether it is suitable to participate in this research

Trial population

All community-children from slelected communities aged 1 to 3 who receive regular child care (programmed immunization vaccination clinic) within a prespecified study period

Trial design

Design model

Family-based

Time perspective

Cross-sectional

Treatments tested in this trial

  • no interventions

    Other intervention

    it is a observational study, do not have interventions.

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

The affected status of Familial Hypercholesterolemia

heterozygote or homozygote carriers of established FH mutations in LDLR, PSCK9 and APOB gene, including mutations included in the FH48 and new ones identified in Chinese children

Time frame
At enrollment

Secondary outcomes

1

fasting total cholesterol level by Fingertip capillary blood test in children around 2 years old

Time frame
At enrollment
2

affected status of known FH mutation

according to FH48

Time frame
At enrollment
3

fasting serum LDL-c levels of children with finger TC over P95

Time frame
At enrollment

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Children's Hospital of Fudan University

Lead sponsor

Source ClinicalTrials.gov
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