We postulate that childhood traumas are associated with deregulation of the glucocorticoid axis and the inflammatory system in obese women. The main objective of the study is to compare the salivary cortisol awaking response in obese women according to the presence of childhood trauma (assessed using the Childhood Trauma Questionnaire, CTQ).
≥18 years female BMI≥30kg/m2
History of bariatric surgery
pregnancy, breastfeeding
hepatocellular insufficiency,
severe heart failure,
Single group
Biological dosage
Biological/VaccineMetabolic, hormonal and psychometric evaluations will be carried out during inclusion inflammatory parameters, hormonal, capillary, saliva and urine assays will also be carried out at inclusion
Measurement of salivary cortisol awakening response (CAR)
Two salivary sampling at Day 0. The CAR is defined as the difference between the value of salivary cortisol collected 30 minutes after waking up and that on waking
Comparison of the amount of urinary free cortisol
Comparison of the amount of urinary free cortisol in obese women according to the presence of childhood trauma (assessed using CTQs)
Comparison of the amount of urinary free cortisol metabolites
Comparison of the amount of urinary free cortisol metabolites in obese women according to the presence of childhood trauma (assessed using CTQs)
Comparison of the amount of salivary cortisone
Comparison of the amount of salivary cortisone in obese women according to the presence of childhood trauma (assessed using CTQs)
Comparison of the amount of hair cortisol/cortisone
Comparison of the amount of hair cortisol/cortisone in obese women according to the presence of childhood trauma (assessed using CTQs)
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