Chinese Occupational Population Cohort of Lifestyle and Physical Fitness (LiFitChina)
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-59
SponsorChina National Center for Cardiovascular Diseases
About this trial
The incidence and prevalence of metabolic risk factors such as obesity, hypertension, diabetes, and dyslipidemia, as well as cardiovascular diseases (CVD), are continuously rising among the occupational population in China, primarily comprising the middle-aged and young adults. Unhealthy lifestyles and declining physical fitness are independent risk factors affecting cardiovascular health. Additionally, the level of physical fitness is influenced by postnatal lifestyles. Lifestyle factors related to cardiovascular health in the occupational population encompass various aspects, including smoking, physical activity, diet, sleep, psychological stress, etc. These factors may interact or have a synergistic effect, necessitating a comprehensive assessment.
This project proposes a prospective cohort study design to establish a monitoring cohort for lifestyle and physical fitness among the occupational population. The study will track and follow individuals with or without any CVD metabolic risk factors, collecting information on general status, lifestyle, physical fitness, and health examination data. Exposure factors such as lifestyle and physical fitness will be measured annually, and the occurrence of CVD-related health outcomes will be observed. The aim is to develop a comprehensive evaluation index for cardiovascular health lifestyle, analyze the direct and indirect impacts of lifestyle and physical fitness on the occurrence and development of CVD, and explore potential mediating and moderating effects of physical fitness in the association between lifestyle and cardiovascular health.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
adults between 18-59 years of age
occupational staff
willing to accept long-term follow-up
Disqualifiers
participants with previous CVD history such as myocardial infarction, stroke and severe aortic stenosis;
with cancer;
with congenital genetic diseases, or cannot cooperate with the investigation and follow-up due to acquired diseases, such as congenital heart disease, paralysis, deafness, dementia, mental abnormality, developmental retardation, etc.;
with exercise contraindications;
Trial population
occupational person free of cardiovascular disease at baseline in China
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
the composite end point of new major adverse cardiovascular events
including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization and unstable angina pectoris requiring hospitalization
Time frame
10 yearsSecondary outcomes
1
new incidence of each major adverse cardiovascular events
new incidence of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, unstable angina requiring hospitalization and other major adverse cardiovascular events
Time frame
10 years2
new incidence of cancer
new incidence of cancer and all-cause death
Time frame
10 years3
new incidence of all-cause death
new incidence of all-cause death
Time frame
10 years4
level of systolic pressure
The level of systolic pressure measured at each follow-up evaluation time point
Time frame
10 yearsSponsors and contacts
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Source ClinicalTrials.gov