Chlordecone Exposure and Female Fertility
ConditionInfertility Female
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-39
SponsorCentre Hospitalier Universitaire de la Guadeloupe
About this trial
Chlordecone is an organochlorine pesticide used in the French West Indies (FWI) from 1972 to 1993 to control the banana root borer. Due to its very long persistence the population continues to be exposed to this chemical through their food consumptions. Although, chlordecone have been associated in animal study impairment of ovarian reserve, to date, no study has been published concerning the link between chlordecone exposure and female fertility. The main objective of this project is to study the association between chlordecone exposure and anti-mullerian hormone (AMH) in women consulting for couple infertility in Guadeloupe.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Women aged from 18 to 39 years
Consulting for couple infertility at the Centre Caribéen de Médecine de la Reproduction (CCMR, Caribbean Center for Reproductive Medicine) of the University Hospital of Guadeloupe
Free, informed and written consent
Disqualifiers
Women aged from 18 to 39 years
Consulting for couple infertility at the Centre Caribéen de Médecine de la Reproduction (CCMR, Caribbean Center for Reproductive Medicine) of the University Hospital of Guadeloupe
Free, informed and written consent
Trial population
Women consulting for couple infertility in Guadeloupe.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Levels of AMH according to terciles of chlordecone levels.
The purpose is to study the association between chlordecone exposure and AMH levels in women consulting for couple infertility in Guadeloupe.
Time frame
AMH levels will be measured during the assessment conducted for assisted reproductive technology (ART) and will date from less than one year before inclusionSecondary outcomes
1
Number of antral follicles according to terciles of chlordecone levels.
Transvaginal ultrasound for antral follicle count will be performed between days 2 and 4 of the spontaneous menstrual cycle, the number of antral follicles corresponds to the total number of antral follicles in both ovaries, with a diameter between 2 and 10 mm.
Time frame
between days 2 and 4 of the spontaneous menstrual cycle2
AMH levels and antral follicle count according to the levels of other POPs
AMH levels and antral follicle count
Time frame
baseline3
relationship between exposure to chlordecone and other POPs and the risk of the main causes of female infertility
main causes of female infertility : Endometriosis ; Polycystic ovary syndrome (PCOS) ; Decreased ovarian reserve
Time frame
baseline4
Chlordecone levels according to the outcomes of IVF/ICSI management:
relationship between occupational exposure to solvents and others factors described : * Endometrial thickness, * Peak estraiol, * Number of oocytes collected, * Number of mature oocytes collected, * Number of zygotes, * Embryo quality, * Blastocyst number, * Number of frozen embryos, * Biological pregnancy, * Clinical pregnancy, * Live birth.
Time frame
changes from baseline to 2 years afterSponsors and contacts
Click on the lead sponsor to view all of their trials.
Centre Hospitalier Universitaire de la Guadeloupe
Lead sponsor
Institut Pasteur de Guadeloupe
Collaborator
Rennes University Hospital
Collaborator
Source ClinicalTrials.gov