Choice of Anticoagulant for Primary Hemostasis Studies With PFA200® (Platelet Function Analyser)

ConditionHemostasis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire Dijon

About this trial

The PFA (platelet function analysis) test is prescribed for the exploration of primary hemostasis and the study of platelet-willebrand factor interaction. It is performed using citrated blood, with technical difficulties and frequent alarms that may be linked to the choice of anticoagulant (citrate). It is proposed to compare the results obtained with a conventional citrate tube and a BAPA tube, which is an anticoagulant used in clinical research and which blocks coagulation by another mechanism that would have less impact on blood platelets.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Person having given their non-opposition

Person of legal age

Person receiving a haemostasis consultation at the haemophilia and haemorrhagic diseases treatment center followed by a blood sample with a PFA test prescribed by the doctor (the test is not added for the study).

Disqualifiers

persons under legal protection (curatorship, guardianship)

persons subject to a court protection order

pregnant, parturient or breast-feeding women

adult incapable or unable to give consent

Trial population

Patients requiring a PFA test

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Sampling of 3 additional BAPA tubes

    Biological/Vaccine

    the 3 additional tubes will be taken at the same time as the blood sample taken for the routine PFA test

Treatment groups

100 Participants
are divided into 1 treatment group
Group A: Patients requiring a PFA test for the diagnosis of Willebrand disease1 intervention

Trial outcomes

Primary outcomes

1

Occlusion time measurement

Measurement of the occlusion times of the 2 cartridges (collagen/ADP and collagen/epinephrine) with the classic 0.109M citrate tube and the BAPA tube, with any PLC alarms and observation of the stained blood smears.

Time frame
at baseline

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.