Health TrialsbyHealthPanel

Choroidal Change on OCTA in Eyes With High Myopia

ConditionsMyopia, ProgressiveChoroid Disease
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-55
SponsorThe First Affiliated Hospital with Nanjing Medical University

About this trial

Myopia is a global healthy concern, especially the high myopia and pathological myopia among Asian populations. However, its mechanism still remains largely unclear. Recent findings suggested choroidal changes might be related to the development of myopia. This study is to useOCT angiography (OCT-A) to investigate parapapillary choroidal microvasculature change in myopic eyes, and try to find the cause-and-effect relationship between choroidal change and the development of myopia.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Spherical equivalent measurement can be included in above 4 groups

Willing to be followed up in the future 10 years

Disqualifiers

Deny to sign the patient consent, or deny to be followed

Evidence of cardiac, or diabetic, or CNS disease.

Clinically diagnosed with retinal or choroidal disease

Glucoma

Trial design

Design model

Parallel

Treatments tested in this trial

  • Optic coherence tomography angiography (OCTA)

    Device

    Using non-invasive, repeatable, mature device OCTA to obtain choroidal angio-map

Treatment groups

200 Participants
are divided into 4 treatment groups
Group A: Group 1/ControlExperimental treatment 1 intervention
Group B: Group 1/MyopiaExperimental treatment 1 intervention
Group C: Group 3/HighExperimental treatment 1 intervention
Group D: Group 4/Super HighExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Parapapillary choroidal microvasculature void (MvV) area

area of parapapillary choroidal microvasculature void on OCTA images

Time frame
changes of MvV area from at 10 years
2

Parapapillary choroidal microvasculature void (MvV) area

area of parapapillary choroidal microvasculature void on OCTA images

Time frame
difference of MvV area in each group at baseline
3

Parapapillary choroidal microvasculature void (MvV) area

area of parapapillary choroidal microvasculature void on OCTA images

Time frame
changes of MvV area at 1 years
4

Parapapillary choroidal microvasculature void (MvV) area

area of parapapillary choroidal microvasculature void on OCTA images

Time frame
changes of MvV area at 3 years

Secondary outcomes

1

MvV number

number of choroidal MvV with certain size

Time frame
baseline
2

Correlation coefficient between choroidal MvV and refractive power

Correlation coefficient between choroidal MvV and refractive power

Time frame
baseline
3

Correlation coefficient between choroidal MvV and PPA area

Correlation coefficient between choroidal MvV and parapapillary atrophy beta area

Time frame
baseline
4

Correlation coefficient between choroidal MvV and choroid thickness

Correlation coefficient between choroidal MvV and choroid thickness

Time frame
baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

The First Affiliated Hospital with Nanjing Medical University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: