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Chronic Effect of Whole-body Electrical Stimulation in COPD Patients

ConditionChronic Obstructive Pulmonary Disease (COPD)
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorFederal University of Health Science of Porto Alegre

About this trial

Randomized clinical trial. Patients with chronic obstructive pulmonary disease (COPD) GOLD III or IV will undergo 16 sessions of Whole-body Electrical Stimulation (WB-EMS) or pulmonary rehabilitation (PR), twice a week. WB-EMS will be performed in association with squats, biceps and triceps exercises, climbing up and down a step, and abdominal exercises. There will be a progression in the number of muscle contractions after the fourth (from 64 to 96) and tenth sessions (96 to 120). PR will consist of upper and lower limb strengthening exercises. Both groups will perform aerobic exercise (essential component of the pulmonary rehabilitation program). Peripheral muscle strength (dynamometry), respiratory muscle strength (maximum inspiratory and expiratory pressure), muscle thickness (ultrasound), functional capacity (6MWT), quality of life (Saint George's Respiratory Questionnaire), inflammatory profile (PCR, IL-6 e IL-10, TNFα), oxidative stress (protein oxidation, superoxide dismutase and catalase, total hydrogen sulfides, dichlorofluorescein diacetate) will be assessed before and after the 16 sessions.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Diagnosis of COPD GOLD 3 and 4;

Age between 18 and 80 years;

Ability to ambulate.

Disqualifiers

Cognitive dysfunction that prevents assessments from being carried out, as well as inability to understand and sign the informed consent form (ICF);

Intolerance to the electrostimulator and/or change in skin sensitivity;

Patients with stroke sequelae;

Recent acute myocardial infarction (two months);

Trial design

Design model

Parallel

Treatments tested in this trial

  • Whole-body electrical stimulation

    Other intervention

    Performed using Miha Bodytec equipment, properly calibrated, with electrodes on the quadriceps, hamstrings, glutes, biceps, triceps, pectorals, abdomen, trapezius, latissimus dorsi and quadratus lumborum muscles.

  • Rehabilitation

    Other intervention

    Pulmonary rehabilitation program.

Treatment groups

16 Participants
are divided into 2 treatment groups
Group A: whole-body electrical stimulationExperimental treatment 1 intervention
Group B: RehabilitationOther 1 intervention

Trial outcomes

Primary outcomes

1

Peripheral muscle strength

Peripheral muscle strength will be assessed by maximum isometric strength of the knee extensor, elbow flexor and palmar flexor muscles using a hand-held dynamometer

Time frame
Baseline
2

Peripheral muscle strength

Peripheral muscle strength will be assessed by maximum isometric strength of the knee extensor, elbow flexor and palmar flexor muscles using a hand-held dynamometer

Time frame
Two months

Secondary outcomes

1

Maximum inspiratory pressure

Maximum inspiratory pressure will be assessed by manovacuometry.

Time frame
Baseline
2

Maximum inspiratory pressure

Maximum inspiratory pressure will be assessed by manovacuometry.

Time frame
Two months
3

Maximum expiratory pressure

Maximum expiratory pressure will be assessed by manovacuometry.

Time frame
Baseline
4

Maximum expiratory pressure

Maximum expiratory pressure will be assessed by manovacuometry.

Time frame
Two months

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Federal University of Health Science of Porto Alegre

Lead sponsor

Santa Casa de Porto Alegre

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: