Circadian Rhythms in Human Adipose
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-55
SponsorMayo Clinic
About this trial
The goal of this study is to understand the underlying circadian rhythms in subcutaneous adipose tissue of humans with our without continuous feeding and how these are altered in people who have obesity.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
BMI 20-25 kg/m2 or 30-37 kg/m2
For participants with obesity a waist-to-hip ratio of ≥0.95 in males and ≥0.90 in females.
sedentary
females: non pregnant or breastfeeding
Disqualifiers
History of mediations that impact adipocyte/lipid metabolism
smoking
insomnia
sleep apnea
Trial design
Design model
Parallel
Treatments tested in this trial
Continuous Feeding
Other interventionParticipants will receive 24-hour continuous feeds through an NG tube
Intermittent feeding
Other interventionParticipants will receive 3 boluses of feeding per day at regular meal times through an NG tube to mimic normal meals.
Treatment groups
40 Participants
are divided into 2 treatment groupsGroup A: Normal weight participantsActive comparator 2 interventions
Group B: Participants with obesityActive comparator 2 interventions
Trial outcomes
Primary outcomes
1
rhythmicity of circadian clock mRNA in adipose tissue
Genes from RNA-seq analysis will be defined as statistically rhythmic.
Time frame
24 hourSponsors and contacts
Click on the lead sponsor to view all of their trials.
Mayo Clinic
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Source ClinicalTrials.gov