Circulating circRNA in Acute Ischemic Stroke
ConditionAcute Ischemic Stroke
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorThe Affiliated Hospital of Xuzhou Medical University
About this trial
CRAST is to analyze the expression pattern of circular RNA (circRNA) by bioinformatics analysis in patients with acute ischemic stroke and healthy control. The candidate circRNA will be verified as biomarkers for the detection and prognosis of acute ischemic stroke.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Aged 18 years or older
Confirmed acute ischemic stroke by a diffusion-weighted imaging-position lesion on magnetic resonance imaging (MRI) and a new lesion on a brain computed tomography (CT) scan
Within 72 hours of symptom onset
Good performance status
Disqualifiers
a history of hemorrhagic infarction, chronic kidney/liver diseases, peripheral arterial occlusive disease, active malignant disease, and inflammatory or infectious diseases
Trial population
There will be 100 patients suspected of AIS (such as transient ischemic attack), 300 AIS patients and 100 Healthy controls，whose data will be applied for construction and validation of diagnostic and predictive models of circRNA from the circulating blood.
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
Quantitative Real-time polymerase chain reaction
GeneticQuantitative Real-time polymerase chain reaction of circular RNA (circRNA).
Treatment groups
500 Participants
are divided into 2 treatment groupsGroup A: AIS group1 intervention
Group B: HC group1 intervention
Trial outcomes
Primary outcomes
1
Differential expression pattern of circRNA
Differential expression pattern of circular RNA (circRNA) will be compared between AIS group and HC group, thus candidate circRNA will be verified as biomarkers for the detection and prognosis of AIS.
Time frame
90 daysSecondary outcomes
1
Dynamic changes of circRNA during the follow-up period
Dynamic changes of circRNA will be explored before and after endovascular therapy
Time frame
90 days2
Correlation of circRNA and stroke-associated infection
Correlation of circRNA and stroke-associated infection will be explored in acute ischemic stroke.
Time frame
30 days3
Correlation of circRNA and inflammatory factors in acute ischemic stroke
Correlation of circRNA and inflammatory factors on admission will be explored in acute ischemic stroke.
Time frame
7 days4
Prognostic value of circRNA in acute ischemic stroke
The prognosis of AIS patients will be analyzed between differential expressed candidate circRNA after they have completed the systematic therapy.
Time frame
90 daysSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov