Health Trials

Clinical and Immunological Evaluation of HA in Treatment of Periodontitis

ConditionPeriodontitis
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-60
SponsorSana'a University

About this trial

To evaluate the immunological effectiveness of Hyaluronic acid as adjunction treatment to scaling and root planning and scaling and root planning alone.

Comparison between clinical measurement before and after treatment. Evaluate the level of IGF-1 in treated site as immunological marker if periodontal regeneration.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

systemically healthy.

at least 20 teeth and suffers from moderate <7mm to severe. >8mm.periodontitis with probing depth >5m and in the contralateral side.

ability to attend to the clinic in a regular manner.

Disqualifiers

allergy to HA.

Chronic disease.

orthodontic treatment.

Qat chewer and smokers.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Hyaluronic acid

    Drug

    Gengigel syringe containing 1ml of 0.8% HA

  • scaling and root planning

    Behavioral

    scaling and root planning using ultrasonic scaler

Treatment groups

24 Participants
are divided into 2 treatment groups
Group A: scaling and root planning with Hyaluronic acid applicationExperimental treatment 2 interventions
Group B: scaling and root planning onlyExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Changes in Plaque Index

ranges from 0 to 3 score, where increasing in number indicates the worst case.

Time frame
From Baseline to 12th weeks post intervention '' changes from baseline to 12th week"
2

Changes in Gingival Index

Ranges from 0 to 3 stages, where increasing in number indicates the worst case.

Time frame
From Baseline to 12th weeks post intervention '' changes from baseline to 12th week"
3

Changes in Papillary Bleeding Index.

Ranges from 0 to 4 score, where increasing in number indicates the worst case

Time frame
From Baseline to 12th weeks post intervention '' changes from baseline to 12th week"
4

Periodontal Probing Depth

distance from the gingival margin to the base of the pocket

Time frame
From Baseline to 12th weeks post intervention '' changes from baseline to 12th week"

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sana'a University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: