Clinical and Microbiological Approach in Orthopedic Treatment of Patients When Choosing a Structural Material

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age1-1
SponsorSamara State Medical University

About this trial

Today, there is a wide range of structural materials on the market, different in chemical, physical and biological properties, and information about them is very often limited only by the manufacturer's instructions, which allows to determine, at best, only the scope. In this regard, there are difficulties in choosing the optimal material for this particular situation, since without a thorough approach to studying the properties of the main materials used in dentistry, it seems difficult to provide high-quality dental care, the result of which is functional usefulness, aesthetics and durability.The problem of an individual approach to the choice of structural material from the standpoint of personalized medicine is even less studied - there are no data in the literature on the role of normal and pathogenic microflora in the development of destructive changes in structures and the development of complications, taking into account a personalized approach when analyzing the composition of the microbiota of the oral cavity, biochemical parameters of the oral fluid, blood depending on the material from which the structure is made.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • dental prosthetics, biofilm response and oral microbiota

    Diagnostic test

    microbiota, biofilm, oral mucosa

Treatment groups

80 Participants
are divided into 4 treatment groups
Group A: 20 patients with zirconiaExperimental treatment 1 intervention
Group B: 20 e-max patientsExperimental treatment 1 intervention
Group C: 20 patients Cobalt-chromium alloyExperimental treatment 1 intervention
Group D: 20 patients metal-ceramicsExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

microbiological research

Before the installation of an orthopedic structure in the oral cavity, microbiological material is taken from the periodontal cavity of the tooth on which the orthopedic structure will be installed. Next, an orthopedic structure is installed for a period of 1 month, after which the structure is removed from the oral cavity, for re-analysis and comparison of changes in the microbiota of the oral cavity, depending on the selected structural material There will be measurements of the size of the tissues of the oral cavity, depending on the choice of material for prosthetics, using molecular genetic, biochemical, microbiological studies.

Time frame
1 month after placing a crown in the mouth

Secondary outcomes

Other outcomes

Sponsors and contacts

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