Clinical and Radiological Evaluation of Dental Autotransplantation in the Anterior Region in Young Patients
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age7-15
SponsorUniversity of Barcelona
About this trial
This study aims to evaluate the clinical, radiographic, functional, and patient-reported outcomes of premolar autotransplantation used to replace anterior maxillary teeth in young patients. The study has an ambispective observational design, including a retrospective cohort (patients treated between December 2019 and December 2025) and a prospective cohort (patients enrolled until December 2028).
Participants aged 7 to 15 years who received or will receive premolar autotransplantation to replace an anterior tooth will be followed clinically and radiographically for up to 5 years. Outcomes include tooth survival, periodontal and pulpal healing, root development, complications, orthodontic interactions, restorative needs, and patient satisfaction. The study seeks to identify prognostic factors and long-term success indicators for dental autotransplantation in growing patients.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients aged 7 to 15 years.
ASA I classification.
Loss or indication for extraction of a maxillary anterior tooth (teeth 12, 11, 21, or 22) due to trauma, resorption, or restorative reasons.
Availability of a donor first or second premolar with root development between one-half and complete root length.
Disqualifiers
Patients older than 15 years.
Severe systemic disease.
Inability or unwillingness to attend scheduled follow-up visits.
Lack of a suitable donor premolar.
Trial population
Young patients aged 7 to 15 years requiring replacement of a maxillary anterior tooth with a premolar autotransplantation at Dental Esthetic BCN, an accredited CEIm-UB clinical center.
Trial design
Design model
Cohort
Time perspective
Other
Treatments tested in this trial
Premolar Autotransplantation
Procedure/SurgeryPremolar autotransplantation performed using a standardized clinical protocol including digital planning (CBCT and STL models), 3D-printed donor tooth replicas, guided or conventional socket preparation, atraumatic donor extraction, extraoral time under 5 minutes and semirigid splinting. Clinical and radiographic follow-up is performed up to 5 years.
Treatment groups
50 Participants
are divided into 1 treatment groupGroup A: Autotransplantation Cohort1 intervention
Trial outcomes
Primary outcomes
1
Number of Autotransplanted Teeth with Clinical and Radiographic Success
Number of autotransplanted teeth that fulfill all predefined success criteria at each follow-up visit: Absence of ankylosis Absence of progressive root resorption Physiological mobility Normal percussion sound Functional stability Absence of clinical signs of infection Each autotransplanted tooth is considered an independent observational unit. In participants with more than one autotransplanted tooth, each tooth is evaluated separately.
Time frame
Up to 5 yearsSecondary outcomes
1
Survival Rate of the Autotransplanted Tooth
Number of autotransplanted teeth remaining in situ without extraction during follow-up.
Time frame
Up to 5 years2
Root Development Stage of the Autotransplanted Tooth
Root development stage of the autotransplanted tooth assessed radiographically using the Moorrees classification.
Time frame
Up to 5 years3
Pulpal Healing Status of the Autotransplanted Tooth
Number of autotransplanted teeth presenting pulpal healing, defined as pulp canal obliteration or maintained pulp vitality without signs of necrosis, based on clinical testing and radiographic findings.
Time frame
Up to 5 years4
Periodontal Probing Depth of the Autotransplanted Tooth
Mean periodontal probing depth (in millimeters) measured at six sites around the autotransplanted tooth.
Time frame
Up to 5 yearsOther outcomes
1
Change in Alveolar Bone Volume at the Autotransplantation Site
Change in alveolar bone volume (in cubic millimeters, mm³) at the autotransplantation site assessed by CBCT superimposition at baseline and follow-up visits, when imaging is clinically indicated.
Time frame
Up to 5 years2
Change in Gingival Tissue Volume at the Autotransplantation Site
Change in gingival tissue volume (in cubic millimeters, mm³) assessed by STL model superimposition at baseline and follow-up visits, when digital models are available.
Time frame
Up to 5 yearsSponsors and contacts
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Source ClinicalTrials.gov