Clinical Characteristics of Patients With Sleep Apnea in Korea

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age19+
SponsorSeoul National University Hospital

About this trial

Sleep-disordered breathing including obstructive sleep apnea (OSA) is an extremely common medical disorder associated with important morbidity. The purpose of this study is to understand the clinical features and course of patients with sleep apnea in Korea. Participants who are suspected of sleep apnea due to symptoms such as snoring, witnessed apneas, waking up with a choking sensation, excessive sleepiness, non-restorative sleep, difficulty initiating or maintaining sleep, fatigue or tiredness, and morning headache will be prospectively recruited at the outpatient clinic of Seoul National University Hospital. After polysomnography (PSG) or respiratory polygraphy, patients with sleep apnea including OSA and central sleep apnea (CSA) will be followed regularly. Participants not having sleep apnea (apnea-hypopnea index \< 5/hour) will only have a baseline visit. For only participants with the informed consent of donating blood, their blood samples will be collected and stored in the Seoul National University Hospital-Human Biobank (SNUH-HUB).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Participants who are suspected of sleep apnea due to symptoms such as snoring, witnessed apneas, waking up with a choking sensation, excessive sleepiness, non-restorative sleep, difficulty initiating or maintaining sleep, fatigue or tiredness, and morning headache

Disqualifiers

None

Trial population

Participants who are suspected of sleep apnea due to symptoms such as snoring, witnessed apneas, waking up with a choking sensation, excessive sleepiness, non-restorative sleep, difficulty initiating or maintaining sleep, fatigue or tiredness, and morning headache will be prospectively recruited at the outpatient clinic of Seoul National University Hospital.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

1,000 Participants
are grouped into 3 trial groups
Group A: obstructive sleep apnea (OSA)
Group B: central sleep apnea (CSA)
Group C: control

Trial outcomes

Primary outcomes

1

The number of participants with adherence to positive airway pressure (PAP) therapy

PAP adherence is defined as the use of PAP therapy for ≥4 h/night on ≥70% of nights

Time frame
Median follow up of 2 years

Secondary outcomes

1

The number of deaths

The number of deaths

Time frame
Median follow up of 15 years
2

The cause of death

The cause of death

Time frame
Median follow up of 15 years

Other outcomes

1

Change of FEV1 and FVC in patients with OSA

Change of forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in patients with OSA

Time frame
Median follow up of 5 years

Sponsors and contacts

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