Clinical Efficacy of Transarterial Infusion Chemotherapy for Unresectable Colorectal Cancer
ConditionUnresectable Colorectal Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorQuanda Liu
About this trial
This is a prospective, multicenter, randomized, open-label clinical trial. It aims to investigate whether intensive transarterial infusion chemotherapy (TAIC) followed by sequential intravenous chemotherapy (IVC) is clinically more effective than IVC alone in the treatment of unresectable colorectal cancer (uCRC).
Eligibility criteria
Qualifiers
None
Disqualifiers
Age ≥ 18 years old;
Histopathologically confirmed CRC adenocarcinoma;
Locally advanced CRC confirmed as clinical T4 stage on CT/MRI imaging, with or without synchronous liver metastases;
For patients with CRLM, hepatic tumor burden shall be lower than the burden of the primary colorectal lesion. Consequently, the multidisciplinary team (MDT) agree by consensus that CRC should be a priority target for treatment.
Trial design
Treatments tested in this trial
- Transarterial infusion chemotherapy (TAIC)
- Intravenous Chemotherapy（IVC）
Treatment groups
50 Participants
are divided into 2 treatment groupsLocations
1Map coordinates are unavailable for these locations. Locations are shown below instead.
Guang'anmen Hospital, China Academy of Chinese Medical SciencesRecruiting100053, Xicheng, Beijing Municipality
China
ChinaSponsors and collaborators
Quanda Liu
Lead sponsor
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Sponsor institution
Liaoning Cancer Hospital & Institute
Collaborator
The Rocket Force Characteristic Medical Center
Collaborator
Second Affiliated Hospital of Nanchang University
Collaborator
Affiliated Hospital of Hebei University
Collaborator
The First Hospital of Qinhuangdao
Collaborator
The Central Hospital of Handan City
Collaborator
The First People's Hospital of Jiujiang City
Collaborator
Changzhi Medical College
Collaborator
Zibo Boshan District Traditional Chinese Medicine Hospital
Collaborator
Hebei Yixian Hospital
Collaborator
Baoding Mancheng District People's Hospital
Collaborator
The Shanghai Yangpu Central Hospital
Collaborator
Source ClinicalTrials.gov