Clinical Prediction Model for Disease Progression in Primary Membranous Nephropathy
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssiut University
About this trial
This prospective observational study aims to evaluate predictors of disease progression in patients with primary membranous nephropathy and to assess the performance of a prognostic nomogram in predicting renal outcomes in the Egyptian population.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥ 18 years
Biopsy-proven primary membranous nephropathy
Written informed consent
Disqualifiers
Secondary membranous nephropathy (e.g., lupus nephritis, hepatitis B or C, malignancy, drug-induced)
Pregnancy
End-stage kidney disease at presentation
Refusal to participate
Trial population
Adults with biopsy-proven primary membranous nephropathy attending the Nephrology Unit, Department of Internal Medicine, Assiut University Hospitals who meet the eligibility criteria.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Performance of the prognostic nomogram in predicting disease progression
Ability of the prognostic nomogram to predict disease progression in patients with primary membranous nephropathy, assessed by the area under the receiver operating characteristic curve (AUC).
Time frame
6 monthsSecondary outcomes
1
Independent clinical and laboratory predictors of disease progression
Identification of independent clinical and laboratory predictors of disease progression in primary membranous nephropathy using multivariable analysis
Time frame
6 months2
Decline in estimated glomerular filtration rate (eGFR)
Change in estimated glomerular filtration rate (eGFR) from baseline, measured in mL/min/1.73 m².
Time frame
6 months3
Remission status
Proportion of patients achieving complete or partial remission according to KDIGO criteria
Time frame
6 month4
Validation of the prognostic nomogram
Validation of the predictive performance of the prognostic nomogram in the local patient population using discrimination and calibration metrics
Time frame
6 monthsLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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