Clinical Retrospective Study Analysis of Postoperative Complications Following Hepatectomy

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorNanfang Hospital, Southern Medical University

About this trial

Hepatectomy is a crucial surgical method for treating liver diseases such as liver cancer, hepatic hemangiomas, and biliary stones. Although hepatectomy has achieved significant therapeutic effects, postoperative complications remain an inevitable issue. Complications following hepatectomy include liver failure, hepatic vascular thrombosis, wound infection at the hepatic incision, and bile leakage, among others. These complications pose a serious threat to patients' health and life, and also increase the waste of medical resources and the cost of treatment. Currently, research on postoperative complications of hepatectomy mainly focuses on small sample studies from a single center, and most studies only focus on a specific complication, lacking comprehensive and systematic analysis. Therefore, it is necessary to conduct a retrospective study analysis of complications related to hepatectomy to more comprehensively and objectively understand the incidence, risk factors, prevention, and treatment of postoperative complications, providing clinical doctors with more scientific treatment plans and guidance.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

1. Patients aged 18-80 years 2.Patients who underwent liver resection surgery at the participating centers

Disqualifiers

Prior cancer treatments such as transarterial chemoembolization, ablation, or targeted therapy.

Repeat liver resection surgeries.

Presence of other malignancies.

Concurrent end-stage diseases including active infections, respiratory failure, decompensated heart failure, and autoimmune disease exacerbations.

Trial population

Patients who underwent liver resection surgery at the participating centers

Trial design

Design model

Cohort

Time perspective

Retrospective

Treatments tested in this trial

  • International Study Group for Liver Surgery (ISGLS)

    Diagnostic test

    According to the ISGLS criteria, the patient was judged to have liver failure and further analysis

Treatment groups

2,000 Participants
are divided into 2 treatment groups
Group A: PHLF/NPHLF1 intervention
Group B: Liver Cirrhosis/No Liver Cirrhosis0 interventions

Trial outcomes

Primary outcomes

1

Post-hepatectomy liver failure (PHLF)

PHLF is commonly diagnosed and classified according to the criteria of the International Study Group for Liver Surgery (ISGLS), utilizing markers of liver function measured on or after postoperative day 5 (POD5).

Time frame
On and after the 5th postoperative day

Secondary outcomes

1

mortality

The patient died postoperatively

Time frame
During 30 days after surgery

Other outcomes

Sponsors and contacts

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