Clinical Study of Intestinal Barrier Dysfunction After Gastrointestinal Surgery

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorThe Second Affiliated Hospital of Kunming Medical University

About this trial

The goal of this observational study is to explore the clinical influences associated with the development of intestinal barrier dysfunction in patients undergoing gastrointestinal surgery. The main question it aims to answer is:What clinical factors increase the probability of developing intestinal barrier dysfunction in patients after gastrointestinal surgery?

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

men or women aged 18-80 years

expected feasible abdominal surgical treatment (partial gastrectomy, colorectal resection)

no preoperative intestinal barrier dysfunction

patients voluntarily participated in this study and signed an informed consent form.

Disqualifiers

Patients or their families refused to participate in this study

chronic inflammatory diseases (e.g. inflammatory bowel disease, chronic hepatitis, chronic pancreatitis, chronic peptic ulcer, etc.)

history of antibiotic administration in the last 2 weeks

severe cognitive impairment and other inability to cooperate preoperative neoadjuvant radiotherapy

Trial population

People undergoing gastrointestinal surgery

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • No intervention was carried out

    Other intervention

    This study is an observational study and no intervention was performed on the patients.

Treatment groups

180 Participants
are divided into 2 treatment groups
Group A: Intestinal barrier dysfunction group1 intervention
Group B: Non-intestinal barrier dysfunction group1 intervention

Trial outcomes

Primary outcomes

1

operating time

Record the patient\'s surgical time

Time frame
During surgery

Secondary outcomes

1

nutritional status

Patients were assessed for risk of malnutrition by the Nutritional Risk Screening Scale (NRS-2002). A score of ≥3 indicated that the patient was at risk of malnutrition.

Time frame
Preoperative
2

bowel habit

The patient was asked whether there were increased frequency of stool, changes in stool characteristics, constipation and other conditions before surgery

Time frame
Preoperative
3

Surgical Procedures

Record whether the patient underwent laparoscopic surgery or open surgery

Time frame
During surgery
4

hemorrhage

Record the patient\'s intraoperative bleeding volume

Time frame
During surgery

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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This trial is not recruiting at the moment. You can still explore other options: