This study aims to establish a novel personalized closed-loop NiBS/TMS therapeutic strategy and clinical protocol for children with Tic Disorders (TDs) through a series of scientific investigations. Additionally, it seeks to elucidate the underlying neural circuit mechanisms, enhance the therapeutic efficacy of TMS in pediatric TDs, and achieve precision neuromodulation for children with TDs.
1: Children and adolescents aged 5 to 18 years
1: WISC-R Full-Scale Intelligence Quotient (FIQ) <70
Parallel
Transcranial Magnetic Stimulation
DeviceTranscranial magnetic stimulation (TMS) will be administered to the child using a ZL-N-010 model device, targeting predefined sites in the prefrontal, bilateral temporal, and parietal lobes.
general behavioral therapy
BehavioralBehavioral interventions include avoiding screen time, parental avoidance of scolding or corporal punishment, and steering clear of activities or emotional stimuli that may exacerbate symptoms.
Tic Severity
The severity of the child's clinical tic symptoms assessed via the Yale Global Tic Severity Scale.
Changes in brain region activation intensity and resting-state connectivity before and after treatment.
Based on fMRI imaging, changes in brain region activation intensity (BOLD signals) and resting-state functional connectivity (FC) before and after treatment were compared.
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