Grounded in the 'disease-syndrome combination' paradigm, this study endeavors to address the pivotal scientific issues pertaining to the clinical precision of Traditional Chinese Medicine (TCM) in managing Diminished Ovarian Reserve (DOR) classified as the Kidney Essence Deficiency type, through the application of systems biology technologies, including metabolomics.
The inclusion criteria are as follows: ① meeting the above-mentioned integrated Chinese and Western medicine diagnostic criteria for DOR
② no use of estrogen-containing medications within the past 1 month
③ patients scheduled to undergo IVF-ET
④ provision of signed informed consent, voluntary participation, and good compliance.
The exclusion criteria are as follows: ① patients with polycystic ovary syndrome (PCOS) or stage III/IV endometriosis
② uterine conditions including untreated submucous myomas, intramural myomas >4 cm in diameter, intrauterine adhesions, uterine septum, or other uterine anomalies
③ couples undergoing preimplantation genetic diagnosis (PGD) for genetic reasons
④ body mass index (BMI) ≥28 kg/m²
Peking Union Medical College Hospital
Lead sponsor
Beijing Municipal Health Commission
Collaborator