Clinical Study on the Effects of Pulmonary Vessels on Cryoablation and Preventive Embolization Strategies

ConditionLung Cancer
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorHaibo Shao

About this trial

This study targeted high-risk individuals with incomplete ablation and performed selective pulmonary artery embolization before lung cryoablation, which could enhance the therapeutic effect and reduce the risk of intraoperative bleeding. Previous studies have shown that selective pulmonary artery embolization before ablation has no adverse reactions related to embolization. In this study, gelatin sponge particles were used for selective pulmonary artery embolization. Gelatin sponge is an absorbable embolic material that can be absorbed and degraded in the human body within about 7 days, which has high safety and a low probability of adverse reactions. The surgical risks are detailed in the surgical protocol. The study aims to optimize the lung cryoablation strategy for high-risk individuals with incomplete ablation, aiming to improve the prognosis of high-risk recurrent patients. The two groups of patients underwent lung CT reexamination every three months after surgery to observe the tumor ablation situation.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Individuals at high risk of incomplete ablation (for example, there are vessels with a diameter greater than 3mm within 1cm around the pulmonary nodule);

Scheduled for lung cryoablation, meeting the surgical indications and without any specific contraindications;

The long diameter of the lung tumor is less than 3cm;

The single cryoablation needle will be used. -

Disqualifiers

Postoperative complications such as massive pneumothorax and bleeding occurred, which affected the observation of the ice ball's shape;

Poor image quality or incomplete images. -

Trial design

Design model

Parallel

Treatments tested in this trial

  • Pulmonary artery embolization

    Procedure/Surgery

    In this study, using DSA guidance, gelatin sponge particles were used to artificially embolize the thicker pulmonary arteries around the tumor, thereby reducing the heat sink effect and complications, and improving the efficacy of lung cryoablation.

Treatment groups

20 Participants
are divided into 2 treatment groups
Group A: experimental groupExperimental treatment 1 intervention
Group B: control groupNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

ablation zone

The CT images obtained during the operation are subjected to three-dimensional reconstruction, and the ROI is delineated. The long diameter, short diameter and volume of the ablation area are measured.Compare the values of various aspects of the smiling areas between the experimental group and the control group.

Time frame
Immediately assess the extent of the ablation after the ablation needle is withdrawn.

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Haibo Shao

Lead sponsor

First Hospital of China Medical University

Sponsor institution

This trial is not recruiting at the moment. You can still explore other options: