The aim of this project is to start a biological and clinical collection of patients presenting autoimmune, dysimmune or auto-inflammatory dermatological diseases. This collection will provide appropriate biological samples to identify new biomarkers and to be accessible to the medical, scientific and industrial communities for the identification of new therapeutic strategies.
Patients with autoimmune bullous dermatoses (pemphigus, pemphigoid and others),
Patients with systemic autoimmune diseases associated with skin damage (lupus, scleroderma, dermatomyositis for example),
Patients with cutaneous lupus
Patients with dysimmune skin diseases (psoriasis, eczema)
Patients under protective supervision (guardianship, curators)
Patients under 6 years old
Pregnant or breastfeeding woman
Patients with autoimmune, dysimmune or auto-inflammatory dermatological disease
Cohort
Prospective
Blood sampling
Biological/VaccineBlood will be taken in larger quantity
Remainders of samples taken as part of the treatment
Biological/Vaccineblood, CSF, saliva, stools, urine, other biological fluids and tissue biopsies, hair follicles
Building a collection of biological samples and clinical-biological data from patients with autoimmune, dysimmune or auto-inflammatory dermatological disease
Blood sampling
Identification of new autoantibodies
Western blot or immunoprecipitation method
Identification of biomarkers regarding the severity (such as cytokines, survival factors) in order to help the therapeutic decisions
Proteomic analysis of sera and plasma samples at diagnosis and during follow up
Exploration of the pathophysiological mechanisms of rare autoimmune dermatological pathologies
Knock-out or knock-in animal models for one specific protein will be used to determine in vivo if the pathophysiological mechanisms of Dermatological Diseases can be induced by the abnormal expression of this protein. Analysis of the phenotypic profiling of blood immune cells by multicolor fluorescence-activated cell sorter (FACS) analysis and of the transcriptomic profiling of blood immune cells by RNA sequencing
Comparison of blood cells populations determinants with flow cytometry, before and after cell therapy and in patients responder or not responder to cell therapy
Exploring blood cell populations before and after cell therapy with flow cytometry
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