Clinimetric Properties of Muscle Mass and Stiffness Measurements of the Quadriceps in Patients With COPD
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorGroupe Hospitalier du Havre
About this trial
A large amount of patients with COPD suffer from muscle dysfunction characterized by losses of muscle mass and strength. Studies have shown an association between a loss of quadriceps muscle mass and premature death.
This study aims to investigate the clinimetric properties of a simple quadriceps perimetry and ShearWave elastography to improve the monitoring of skeletal muscle function in patients with COPD.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
COPD patients
Adults (>18 years old)
Patients starting a pulmonary rehabilitation (PR) programme
Disqualifiers
Patients included in other research protocol
Minors or under guardianship
Pregnancy
Patients with lower limb amputation or history of neuromuscular disease
Trial population
COPD patients completing a PR programme for 5 weeks
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Perimetry and ShearWave measurement of the quadriceps muscle before and after a pulmonary rehabilitation (PR) programme
Diagnostic testPatients will undergo a pulmonary rehabilitation (PR) programme. On day 1, perimetry and ShearWave measurements of the quadriceps muscle will be provided. Supplementary assessments of quadriceps thickness, quadriceps strength with a handheld dynamometry, lean body mass (bioelectrical impedance), constant work-rate endurance test and HAD questionnaire will also be provided on day 1. The same measurements and questionnaire will be provided on the last day of the patient in the PR programme.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Perimetry of the quadriceps
Thigh circumference measured by a tape
Time frame
At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)2
Quadriceps stiffness
ShearWave elastography of the quadriceps muscle
Time frame
At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)Secondary outcomes
1
Lean body mass
measured by bioelectrical impedance
Time frame
At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)2
Functional exercise capacity
measured as the endurance time during a constant load endurance test using a cycloergometer or a treadmill
Time frame
At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)3
Health-Related Quality of Life
measured by quality of life questionnaire (hospital anxiety and depression scale (HAD))
Time frame
At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)4
Quadriceps thickness
measured by ultrasonography
Time frame
At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)Sponsors and contacts
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Source ClinicalTrials.gov