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CMR-derived Quantitative Perfusion for Prediction of FFR

ConditionChronic Coronary Syndrome
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-99
SponsorKerckhoff Klinik

About this trial

Patients will undergo quantitative perfusion assessment in cardiovascular magnetic resonance imaging (dual bolus or dual sequence approach) as well as invasive coronary angiography for assessment of fractional flow reserve (FFR) including assessment of coronary flow reserve (CFR) and microcirculatory resistance (IMR).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

clinical indication for vasodilatator CMR or invasive coronar angiography

capability to give informed consent

Disqualifiers

general: non-compliance, <18 years of age, pregnancy

contraindications for CMR (non-CMR compatible device, chronic kidney disease (eGFR <30ml/min), allergies (medications)

Trial population

All patients referred to the clinical service for ischaemia evaluation

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

200 Participants
are grouped into 1 trial group
Group A: CCS patients

Trial outcomes

Primary outcomes

1

Quantitative Perfusion

Correlation of myocardial blood flow and perfusion reserve in CMR with invasively dervived fractional flow reserve (FFR), coronary flow reserve (CFR) and microcirculatory resistance (IMR)

Time frame
assessment of CMR and invasive data within 24hours
2

Dual bolus vs dual sequence

Compare both CMR-derived quantitative perfusion for prediction of FFR/CFR/IMR

Time frame
assessment of CMR and invasive data within 24hours

Secondary outcomes

1

Strain

Correlation of segmental perfusion and myocardial strain

Time frame
baseline CMR data
2

Tissue characterisation

Correlation of segmental perfusion and T1/T2/ECV/LGE

Time frame
baseline CMR data
3

Cardiovascular Hospitalisation (CVH)

CVH within 12 months

Time frame
12 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Kerckhoff Klinik

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: