About this trial
The development of cognitive dysfunction can profoundly affect HR-QoL as well as the possibility of societal participation and ability to work, and thereby relevantly impacts prospects for cancer survivorship. The aim of the study is to obtain improved understanding of the scope and magnitude of objective cognitive dysfunction in DTC survivors, and its relation to subjective cognitive dysfunction, thyroid hormone levels, physical activity and HRQoL. This is done in a prospective study where patients operated for a thyroid nodule (Bethesda IV-VI, i.e., benign \[goitre with nodule and fibroadenomas\], low-risk DTC and intermediate-high risk DTC) are included and asked to serially perform online neuropsychological testing as well as to complete questionnaires related to HR-QoL, physical activity and additional psychological and physical complaints. Blood is analysed for levels of thyroid hormones and systemic inflammation.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age >18 years old, indication for surgery because of a thyroid nodule Bethesda IV-VI
Able to read and understand the Swedish language
Access to desktop computer or laptop with internet connection
Able and willing to provide written informed consent
Disqualifiers
A previous diagnosis of (auto-immune) hypothyroidism
A previous cancer diagnosis (excluding basal cell cancer of the skin)
Indications for surgery other than (solely) a thyroid nodule (i.e., concomitant Graves)
A diagnosis of medullary and anaplastic thyroid cancer
Trial population
All consecutive patients who are visiting the Medical Unit Endocrine Tumours at the Karolinska University Hospital and scheduled for thyroid surgery for Bethesda IV-VI thyroid lesions, will be informed about the possibility to participate in this study.
Trial design
Cohort
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Objective cognitive functioning by means of an online neuropsychological test (Amsterdam Cognition Scale, ACS)
change in total score on ACS
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Karolinska University Hospital
Lead sponsor
The Netherlands Cancer Institute
Collaborator