Cognitive Dysfunction and Delirium After TUR-M in Elderly Patients
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age65+
SponsorMuğla Sıtkı Koçman University
About this trial
Elderly patients undergoing transurethral resection are at increased risk of postoperative cognitive dysfunction (POCD) and delirium, which are associated with prolonged hospital stay, increased morbidity, and decreased quality of life. Identifying patients who are more likely to develop postoperative cognitive dysfunction or delirium remains a practical challenge in daily clinical practice. Better recognition of these patients may help tailor perioperative care and improve outcomes.
This prospective observational study aims to identify perioperative factors associated with POCD and delirium in elderly patients undergoing transurethral resection and to develop a clinically applicable risk prediction model. Cognitive function and delirium are assessed using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM).
Cognitive function and delirium will be evaluated using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM).
The results of this study may support clinicians in recognizing vulnerable patients earlier and may contribute to more individualized perioperative management.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥65 years
Scheduled for transurethral resection procedure
ASA physical status I-III
Able to provide informed consent
Disqualifiers
Pre-existing diagnosis of dementia or severe cognitive impairment (MoCA <18)
Severe visual or hearing impairment preventing cognitive assessment
History of psychiatric disease requiring antipsychotic or sedative medication
Neurological disorders associated with increased delirium risk (e.g., Parkinson's disease, epilepsy)
Trial population
The study population consists of patients aged 65 years and older undergoing transurethral resection at Mugla Training and Research Hospital. These patients represent an elderly surgical population at risk for postoperative cognitive dysfunction and delirium. Participants are enrolled consecutively according to eligibility criteria and followed throughout the perioperative period.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Cognitive and Delirium Assessment (MoCA and CAM)
Diagnostic testPatients aged 65 years and older undergoing transurethral resection who are followed for the development of postoperative cognitive dysfunction and delirium.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Incidence of postoperative cognitive dysfunction and delirium
Postoperative cognitive dysfunction and delirium assessed using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM). POCD is defined as a decline in MoCA score compared with baseline, and delirium is identified based on CAM criteria.
Time frame
Baseline (preoperative) and postoperative days 1, 2, and 3Secondary outcomes
1
Risk factors associated with POCD and delirium
Evaluation of perioperative variables (demographic characteristics, comorbidities, frailty status, anesthesia type, and intraoperative parameters) associated with the development of POCD and delirium. Evaluation of perioperative variables (demographic characteristics, comorbidities, frailty status, anesthesia type, and intraoperative parameters) associated with the development of POCD and delirium.
Time frame
From baseline (preoperative) through postoperative day 32
Performance of the predictive risk model
Assessment of the predictive model for POCD and delirium using multivariable logistic regression and receiver operating characteristic (ROC) curve analysis.
Time frame
Through study completion (anticipated November 2026)Sponsors and contacts
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Source ClinicalTrials.gov