Cognitive Impairment, Retinopathy, and Cerebrovascular Lesions in the Elderly
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age40+
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University
About this trial
The CIRCLE study is a single-center prospective observational study that enrolled individuals with cerebral small vessel disease (SVD), while free of known dementia or stroke (both cerebral infarction and hemorrhage). The patients will receive neuropsychological testing, retinal digital images and multimodal magnetic resonance imaging (MRI). Blood samples will also be collected. Recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy will be evaluated on both baseline and follow-up brain MRIs. The investigators will explore the predictors of preogression of SVD and cognitive deficits.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adult (≥40y; no upper limit)
Free of known dementia or stroke (both cerebral infarction and hemorrhage)
Disqualifiers
Any MRI contraindications
Serious head injury (resulting to loss of consciousness) or received intracranial surgery
Suffering from cancer
Trial population
Residents of certain towns
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
multimodal magnetic resonance imaging
Other interventionmultimodal magnetic resonance imaging included T1, FLAIR, MRA, PWI and/or ASL, DTI, DKI, SWI, fMRI
Treatment groups
1,000 Participants
are divided into 2 treatment groupsGroup A: Individuals with SVDs1 intervention
Group B: Individuals without SVDs1 intervention
Trial outcomes
Primary outcomes
1
Cognitive state
Cognitive state based on Mini-mental State Examination
Time frame
1yearSponsors and contacts
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Source ClinicalTrials.gov