Cognitive Processing of Natural Sequences in Humans and Artificial Intelligence (AI)

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-85
SponsorInstitut Pasteur

About this trial

The goal of this study is to identify electrical patterns in the cortex that enable the generation of predictions in natural auditory sequences such as speech and music.

Between 500 and 700 participants in total (250 to 350 normally hearing participants (including 60 to 120 participants from West Africa and 60 to 120 participants from Western Europe) and 250 to 350 participants with hearing loss (no restrictions on origin)).

Participants will listen to naturally recorded music and speech via headphones. They will be asked to rate these stimuli on a scale from 0 to 10 in terms of pleasure and comprehension, using a keyboard and mouse or voice input. Additionally, they will be required to sing or produce novel/improvised vocal responses using high-fidelity microphones. This entire procedure will be conducted under electroencephalography (EEG) to record neuronal responses throughout the process.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Average pure-tone thresholds ≤ 20 dB HL

Average pure-tone thresholds > 20 dB HL

Average pure-tone thresholds ≤ 20 dB HL

Declare that both parents are of West African origin, either by their own birth or by the birth of both of their parents.

Disqualifiers

No known neurological or audiological disorders

Participants under legal guardianship (tutelle, curatelle)

Participants deprived of legal liberty by judicial or administrative decision

Trial population

Hearing participants will be recruited from the general population in the Paris region. We will also recruit participants with hearing impairment through ENT clinics, in hearing aid dispensing centers. Finally, we will specifically recruit participants residing in Paris and of West African origin to examine differences related to cultural experience.

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

700 Participants
are grouped into 3 trial groups
Group A: Normal hearing participants from West Africa
Group B: Normal hearing participants from Western Europe
Group C: Participants with hearing loss

Trial outcomes

Primary outcomes

1

Correlation between neural recordings and IA models

To identify electrical patterns in cortex which generates predictions in natural auditory sequences (such as speak and music).

Time frame
Day 1

Secondary outcomes

1

Compare predictions generated across different cultural contexts

specifically, comparing West African and Western European communities in Paris

Time frame
Day 1
2

Compare predictions for identical stimuli across repeated sessions to establish a link between processing and successful memorization/retention.

Time frame
From enrollement to visit 2 (10 days)
3

Compare predictions generated between hearing individuals and those with hearing impairments.

Time frame
Day 2
4

Correlate predictive measures with responses to autism symptom questionnaires across the various experiments.

Time frame
Day 1

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Institut Pasteur

Lead sponsor

IHU reConnect

Collaborator

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