About this trial
The goal of this study is to identify electrical patterns in the cortex that enable the generation of predictions in natural auditory sequences such as speech and music.
Between 500 and 700 participants in total (250 to 350 normally hearing participants (including 60 to 120 participants from West Africa and 60 to 120 participants from Western Europe) and 250 to 350 participants with hearing loss (no restrictions on origin)).
Participants will listen to naturally recorded music and speech via headphones. They will be asked to rate these stimuli on a scale from 0 to 10 in terms of pleasure and comprehension, using a keyboard and mouse or voice input. Additionally, they will be required to sing or produce novel/improvised vocal responses using high-fidelity microphones. This entire procedure will be conducted under electroencephalography (EEG) to record neuronal responses throughout the process.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Average pure-tone thresholds ≤ 20 dB HL
Average pure-tone thresholds > 20 dB HL
Average pure-tone thresholds ≤ 20 dB HL
Declare that both parents are of West African origin, either by their own birth or by the birth of both of their parents.
Disqualifiers
No known neurological or audiological disorders
Participants under legal guardianship (tutelle, curatelle)
Participants deprived of legal liberty by judicial or administrative decision
Trial population
Hearing participants will be recruited from the general population in the Paris region. We will also recruit participants with hearing impairment through ENT clinics, in hearing aid dispensing centers. Finally, we will specifically recruit participants residing in Paris and of West African origin to examine differences related to cultural experience.
Trial design
Case-control
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Correlation between neural recordings and IA models
To identify electrical patterns in cortex which generates predictions in natural auditory sequences (such as speak and music).
Secondary outcomes
Compare predictions generated across different cultural contexts
specifically, comparing West African and Western European communities in Paris
Compare predictions for identical stimuli across repeated sessions to establish a link between processing and successful memorization/retention.
Compare predictions generated between hearing individuals and those with hearing impairments.
Correlate predictive measures with responses to autism symptom questionnaires across the various experiments.
Locations
Sponsors and contacts
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Institut Pasteur
Lead sponsor
IHU reConnect
Collaborator
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