About this trial
Populations facing health disparities include groups with significantly higher rates of posttraumatic stress disorder than the general population who frequently experience lived experience stress, which may complicate posttraumatic stress disorder symptom presentations. However, there are currently no posttraumatic stress disorder treatments designed to meet the unique needs of these individuals.
The proposed study will pilot an adaptation of Cognitive Processing Therapy (a gold-standard treatment for posttraumatic stress disorder) that has been modified to incorporate the impact of lived experience stress as an additional treatment target. This project has the potential to advance our understanding of how to enhance Cognitive Processing Therapy in order to optimize posttraumatic stress disorder treatment response and mitigate health disparities.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Current diagnosis of PTSD
Self-identification as a sexual or gender minority (SGM) individual
Endorsement of SGM stress experiences with moderate distress
For patients who take psychiatric medication, stable dose one month prior to enrollment
Disqualifiers
Current active suicidal or homicidal ideation with intent or plan
Unstable bipolar disorder/current mania
Unstable psychotic disorder/current psychosis
Current severe substance use that warrants immediate medical attention
Trial design
Parallel
Treatments tested in this trial
Standard CPT
BehavioralCPT focuses on teaching skills to identify and challenge PTSD-maintaining maladaptive beliefs related to the trauma itself, the world, and oneself. Worksheets and assignments are given between each session.
CPT-LEAP
BehavioralCPT-LEAP frames each session in relation to beliefs about both traumatic and lived experience stressors and their interactions and impacts, including not only beliefs about oneself, others, and the world, but also one's identity, and use of relevant examples throughout the protocol.
Treatment groups
Trial outcomes
Primary outcomes
Post traumatic stress disorder symptoms (PTSD)
Clinician-Administered PTSD Scale for Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 (CAPS-5). The CAPS-5 includes 20 items assessing PTSD symptom severity. Total scores range from 0-80 with higher scores indicating more severe PTSD symptoms.
Sponsors and contacts
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Boston University
Lead sponsor
National Institute of Mental Health (NIMH)
Collaborator
This trial is not recruiting at the moment. You can still explore other options: